Topoisomerase 1-dependent Mutagenesis in Saccharomyces cerevisiae
<p>Topoisomerase 1 (Top1) resolves transcription-associated supercoils by generating transient single-strand breaks in DNA and is a major source of transcription-associated mutagenesis in Saccharomyces cerevisiae. Top1 generates a distinctive mutation signature characterized by deletions in s...
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2015
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| Online Access: | http://hdl.handle.net/10161/11386 |