Development and Application of Covalent-Labeling Strategies for the Large-Scale Thermodynamic Analysis of Protein Folding and Ligand Binding

Development and Application of Covalent-Labeling Strategies for the Large-Scale Thermodynamic Analysis of Protein Folding and Ligand Binding

<p>Thermodynamic stability measurements on proteins and protein-ligand complexes can offer insights not only into the fundamental properties of protein folding reactions and protein functions, but also into the development of protein-directed therapeutic agents to combat disease. Conventional...

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Bibliographic Details
Main Author: Xu, Yingrong
Other Authors: Fitzgerald, Michael C
Published: 2016
Subjects:
Chemistry
Biochemistry
covalent labeling
ligand binding
mass spectrometry
protein-ligand binding
protein thermodynamic stability
proteome-wide
Online Access:http://hdl.handle.net/10161/12204

Internet

http://hdl.handle.net/10161/12204

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