Exploring the Immunogenicity and Therapeutic Applications of Boranophosphate-modified RNA: siRNA and RNA Aptamers

Exploring the Immunogenicity and Therapeutic Applications of Boranophosphate-modified RNA: siRNA and RNA Aptamers

<p>Borane (BH<sub>3<sub>) chemistry offers unique chemical characteristics that enable boranophosphate (BP) oligonucleotides with potential to enhance RNA therapeutic applications such as RNA interference (RNAi) and RNA aptamers. Further, BP nucleotides are substrates for RNA polym...

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Bibliographic Details
Main Author: Sharaf, Mariam Lucila
Other Authors: Shaw, Barbara R
Published: 2011
Subjects:
Chemistry
Biochemistry
Molecular Biology
aptamers
boranophosphate RNA
gemcitabine
siRNA
T7 RNA polymerase
Toll like receptors
Online Access:http://hdl.handle.net/10161/3882

Internet

http://hdl.handle.net/10161/3882

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