Direct Carbon-Carbon Bond Formation via Base Mediated and Reductive Soft Enolization of Thioesters, the First Asymmetric Total Synthesis of (+)- and (-)-Clusianone, and Progress Toward the Asymmetric Total Synthesis of Brasilicardin A

Direct Carbon-Carbon Bond Formation via Base Mediated and Reductive Soft Enolization of Thioesters, the First Asymmetric Total Synthesis of (+)- and (-)-Clusianone, and Progress Toward the Asymmetric Total Synthesis of Brasilicardin A

<p>Three methodology studies and two total synthesis endeavors are presented. First, a study of Lewis acid and hydrogen bond mediated soft enolization of thioesters and their addition to imines in the Mannich reaction is reported. MgBr2*OEt2 and Hunig's base are used in concert with bul...

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Bibliographic Details
Main Author: Garnsey, Michelle Renee
Other Authors: Coltart, Don M
Published: 2012
Subjects:
Organic chemistry
asymmetric alkylation
brasilicardin
carbon-carbon bond
clusianone
Soft Enolization
thioester
Online Access:http://hdl.handle.net/10161/5573

Internet

http://hdl.handle.net/10161/5573

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