Structural Mechanisms of Accurate and Mutagenic DNA Replication

<p>High-fidelity DNA polymerases achieve remarkable accuracy by exhibiting exquisite nucleotide substrate selection mechanisms. DNA polymerases not only discriminate highly against base-pair mismatches, but also show a high degree of selectivity for the correct sugar moiety deoxyribonucleotide...

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Bibliographic Details
Main Author: Wang, Weina
Other Authors: Beese, Lorena S
Published: 2012
Subjects:
Online Access:http://hdl.handle.net/10161/5607