Cerebral Cavernous Malformations: From Two-Hit Mechanism to Developing a Targeted Therapy

Cerebral Cavernous Malformations: From Two-Hit Mechanism to Developing a Targeted Therapy

<p>Cerebral cavernous malformations (CCMs) are multicavernous vascular lesions affecting the central nervous system. Affected individuals have a lifetime risk of recurrent headaches, focal neurological deficits, seizures, and intracerebral hemorrhage leading to stroke. Patients tend to fall...

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Bibliographic Details
Main Author: McDonald, David Andrew
Other Authors: Marchuk, Douglas A
Published: 2013
Subjects:
Genetics
Molecular biology
Cerebral cavernous malformations
Mouse
RhoA
Sequencing
Somatic mutation
Online Access:http://hdl.handle.net/10161/7133

Internet

http://hdl.handle.net/10161/7133

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