Synthesis of Chemical Models of Hydrolase Enzymes for Intramolecular Catalysis.
Most nuclease enzymes can hydrolyze phosphoester bonds (in DNA and RNA) by using metal ions cofactors that coordinate and activate water molecules in the enzymes' active sites. However, there are some hydrolase enzymes (including nucleases) that can function without the aid of metal ions. 2,6-D...
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Digital Commons @ East Tennessee State University
2011
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| Online Access: | https://dc.etsu.edu/etd/1356 https://dc.etsu.edu/cgi/viewcontent.cgi?article=2547&context=etd |