Treatment-Naïve HIV-Infected Patients Have Fewer Gut-Homing β7 Memory CD4 T Cells than Healthy Controls

Treatment-Naïve HIV-Infected Patients Have Fewer Gut-Homing β7 Memory CD4 T Cells than Healthy Controls

OBJECTIVES: The integrin α4β7 is the gut-homing receptor for lymphocytes. It also is an important co-receptor for human immunodeficiency virus (HIV) via glycoprotein (gp)120 binding. Depletion of gut cluster of differentiation (CD)4 T cells is linked to chronic inflammation in patients with HIV; how...

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Bibliographic Details
Main Authors: Fadul, Nada, Couturier, Jacob, Yu, Xiaoying, Kozinetz, Claudia A., Arduino, Roberto, Lewis, Dorothy E.
Published: Digital Commons @ East Tennessee State University 2017
Subjects:
adult
case-control studies
CD4 antigens
CD4 lymphocyte count
CD4-positive t-lymphocytes
female
flow cytometry
HIV infections
humans
integrin beta chains
leukocyte common antigens
lymphocyte count
male
middle aged
receptors
CXCR4
lymphocyte homing
viral load
young adult
Biostatistics and Epidemiology
Maternal Child Health
Epidemiology
Virus Diseases
Online Access:https://dc.etsu.edu/etsu-works/1497
https://doi.org/10.14423/SMJ.0000000000000730

Internet

https://dc.etsu.edu/etsu-works/1497
https://doi.org/10.14423/SMJ.0000000000000730

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