Dopamine D2 Receptor Supersensitivity as a Spectrum of Neurotoxicity and Status in Psychiatric Disorders

Dopamine D2 Receptor Supersensitivity as a Spectrum of Neurotoxicity and Status in Psychiatric Disorders

Abnormality of dopamine D2 receptor (D2R) function, often observed as D2R supersensitivity (D2RSS), is a commonality of schizophrenia and related psychiatric disorders in humans. Moreover, virtually all psychotherapeutic agents for schizophrenia target D2R in brain. Permanent D2RSS as a feature of a...

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Bibliographic Details
Main Authors: Kostrzewa, Richard M., Wydra, Karolina, Filip, Malgorzata, Crawford, Cynthia, McDougall, Sanders A., Brown, Russell W., Borroto-Escuela, Daniel O., Fuxe, Kjell, Gainetdinov, Raul R.
Published: Digital Commons @ East Tennessee State University 2018
Subjects:
ADHD
animal models
behavioral sensitization
dopamine receptors
schizophrenia
Biomedical Sciences
Neurosciences
Online Access:https://dc.etsu.edu/etsu-works/2770
https://doi.org/10.1124/jpet.118.247981

Internet

https://dc.etsu.edu/etsu-works/2770
https://doi.org/10.1124/jpet.118.247981

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