Inhibition of TRF2 Accelerates Telomere Attrition and DNA Damage in Naïve CD4 T Cells During HCV Infection

Inhibition of TRF2 Accelerates Telomere Attrition and DNA Damage in Naïve CD4 T Cells During HCV Infection

T cells play a crucial role in viral clearance and vaccine responses; however, the mechanisms that regulate their homeostasis during viral infections remain unclear. In this study, we investigated the machineries of T-cell homeostasis and telomeric DNA damage using a human model of hepatitis C virus...

Full description

Bibliographic Details
Main Authors: Nguyen, Lam Nhat, Zhao, Juan, Cao, Dechao, Dang, Xindi, Wang, Ling, Lian, Jianqi, Zhang, Ying, Jia, Zhansheng, Wu, Xiao Y., Morrison, Zheng, Xie, Qian, Ji, Yingjie, Zhang, Zheng, El Gazzar, Mohammed, Ning, Shunbin, Moorman, Jonathan P., Yao, Zhi Q.
Format: Others
Published: Digital Commons @ East Tennessee State University 2018
Subjects:
TRF2
telomere attrition
naïve CD4
HCV Infection
Internal Medicine
Online Access:https://dc.etsu.edu/etsu-works/6523
https://dc.etsu.edu/cgi/viewcontent.cgi?article=7774&context=etsu-works

Internet

https://dc.etsu.edu/etsu-works/6523
https://dc.etsu.edu/cgi/viewcontent.cgi?article=7774&context=etsu-works

Similar Items