The Multifunctional Protein p62 and Its Mechanistic Roles in Cancers
The multifunctional signaling hub p62 is well recognized as a ubiquitin sensor and a selective autophagy receptor. As a ubiquitin sensor, p62 promotes NFκB activation by facilitating TRAF6 ubiquitination and aggregation. As a selective autophagy receptor, p62 sorts ubiquitinated substrates including...
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Digital Commons @ East Tennessee State University
2019
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| Online Access: | https://dc.etsu.edu/etsu-works/6539 https://doi.org/10.2174/1568009618666181016164920 |