Altered Expression of Phox2 Transcription Factors in the Locus Coeruleus in Major Depressive Disorder Mimicked by Chronic Stress and Corticosterone Treatment in Vivo and in Vitro

Altered Expression of Phox2 Transcription Factors in the Locus Coeruleus in Major Depressive Disorder Mimicked by Chronic Stress and Corticosterone Treatment in Vivo and in Vitro

Phox2a and Phox2b are two homeodomain transcription factors playing a pivotal role in the development of noradrenergic neurons during the embryonic period. However, their expression and function in adulthood remain to be elucidated. Using human postmortem brain tissues, rat stress models and culture...

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Bibliographic Details
Main Authors: Fan, Yan, Chen, Ping, Raza, Muhammad U., Szebeni, Attila, Szebeni, Katalin, Ordway, Gregory A., Stockmeier, Craig A., Zhu, Meng Yang
Format: Others
Published: Digital Commons @ East Tennessee State University 2018
Subjects:
corticosterone
locus coeruleus
major depressive disorder
Phox2 genes
postmortem
stress
Biomedical Sciences
Online Access:https://dc.etsu.edu/etsu-works/8593
https://dc.etsu.edu/cgi/viewcontent.cgi?article=9857&context=etsu-works

Internet

https://dc.etsu.edu/etsu-works/8593
https://dc.etsu.edu/cgi/viewcontent.cgi?article=9857&context=etsu-works

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