X-ray structures of p22 c2 repressor-dna complexes: the mechansism of direct and indirect readout

The P22 c2 repressor protein (P22R) binds to DNA sequence-specifically and helps direct the temperate lambdoid bacteriophage P22 to the lysogenic developmental pathway. To gain insight into its DNA binding mechanism, we solved the 1.6 Å x-ray structure of the N-terminal domain (NTD) of P22R in a com...

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Bibliographic Details
Main Author: Watkins, Jason Derrick
Published: Georgia Institute of Technology 2009
Subjects:
Online Access:http://hdl.handle.net/1853/26709