Molecular dynamics simulations of binding, unfolding, and global conformational changes of signaling and adhesion molecules

Molecular dynamics simulations of binding, unfolding, and global conformational changes of signaling and adhesion molecules

Molecular dynamics (MD) simulations were used to investigate the structural basis for the functions of three proteins: Fc(gamma) receptor III (CD16), von Willebrand factor (VWF), and integrin. CD16, a heavily glycosylated protein expressed on human immune cells, plays a crucial role in immune defens...

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Bibliographic Details
Main Author: Chen, Wei
Published: Georgia Institute of Technology 2009
Subjects:
Global conformational changes
Structural unfolding
Binding free energy
Integrin
Molecular dynamics
Von Willebrand factor
Fc gamma receptor III
Molecular dynamics Computer simulation
Conformational analysis
Proteins
Protein folding
Protein binding
Online Access:http://hdl.handle.net/1853/28118

Internet

http://hdl.handle.net/1853/28118

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