Local and sustained delivery of hydrophobic drugs to the spinal cord with polyketal microparticles

Local and sustained delivery of hydrophobic drugs to the spinal cord with polyketal microparticles

Amyotrophic lateral sclerosis (ALS) is a devastating disease. Currently, there is no cure for this disease, and effective treatment strategies are greatly needed. Calpain activation plays a major role in the motor neuron degeneration that causes ALS. Therefore, therapeutic strategies can inhibit c...

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Bibliographic Details
Main Author: Kao, Chen-Yu
Published: Georgia Institute of Technology 2011
Subjects:
Microparticle
Polyketal
Sustained release
Amyotrophic lateral sclerosis
Intrapinal cord injection
Drug delivery
Hydrophobic
Calpain inhibitors
Calpain
Polymeric drug delivery systems
Polymers in medicine
Biomedical materials
Online Access:http://hdl.handle.net/1853/37304

Internet

http://hdl.handle.net/1853/37304

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