Mutational analysis and engineering of the human vitamin D receptor to bind and activate in response to a novel small molecule ligand
Nuclear receptors (NRs) are ligand-activated transcription factors that regulate the expression of genes involved in all physiological activities. Disruption in NR function (e.g. mutations) can lead to a variety of diseases; making these receptors important targets for drug discovery. The ability to...
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Georgia Institute of Technology
2011
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| Online Access: | http://hdl.handle.net/1853/39502 |