Studies of genetic factors modulating polyglutamine toxicity in the yeast model
Polyglutamine-expanded fragments, derived from the human huntingtin protein, are aggregation-prone and toxic in yeast cells, bearing endogenous QN-rich proteins in the aggregated (prion) form. Attachment of the proline-rich region targets polyglutamine aggregates to the large perinuclear deposit (ag...
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Georgia Institute of Technology
2012
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| Online Access: | http://hdl.handle.net/1853/42796 |