Regulation of the cardiac isoform of the ryanodine receptor by S-adenosyl-l-methionine

Regulation of the cardiac isoform of the ryanodine receptor by S-adenosyl-l-methionine

Activity of the Ryanodine Receptor (RyR2) (aka cardiac Ca2+ release channel) plays a pivotal role in contraction of the heart. S-adenosyl-l-methionine (SAM) is a biological methyl group donor that has close structural similarity to ATP, an important physiological regulator of RyR2. This work provid...

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Bibliographic Details
Main Author: Gaboardi, Angela Kampfer
Published: Georgia Institute of Technology 2012
Subjects:
Methylation
Ryanodine receptor
S-adenosyl-l-methionine
Subconductance
Adenine nucleotides
ATP
Ion channels
Ryanodine Receptors
Calcium channels
Muscle contraction
Online Access:http://hdl.handle.net/1853/42854

Internet

http://hdl.handle.net/1853/42854

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