Shear stress, hemodynamics, and proteolytic mechanisms underlying large artery remodeling in sickle cell disease

Sickle cell disease is a genetic disorder that affects 100,000 Americans and millions more worldwide. Although the sickle mutation affects one protein, which is only expressed in a single cell type, it has profound detrimental effects on nearly every organ system in the body. Young children with s...

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Bibliographic Details
Main Author: Keegan, Philip Michael
Other Authors: Platt, Manu O.
Format: Others
Language:en_US
Published: Georgia Institute of Technology 2016
Subjects:
Online Access:http://hdl.handle.net/1853/54289