Binding, Bending and G Jumping in the Minor Groove: Experimental and Theoretical Approaches
It has been shown that heterocyclic diamidines, a class of minor groove binders, are promising antimicrobial agents. These compounds bind none covalently to the minor groove of A/T rich regions of the kinetoplast DNA and kill the parasite. The mechanism of action of these compounds is not well under...
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| Format: | Others |
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Digital Archive @ GSU
2008
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| Online Access: | http://digitalarchive.gsu.edu/chemistry_diss/27 http://digitalarchive.gsu.edu/cgi/viewcontent.cgi?article=1026&context=chemistry_diss |