Two-site DNA Minor Groove Binding Compounds
DNA minor groove binding compounds have had limited therapeutic uses, in part due to problems with sequence specificity. A two-site model has been developed to enhance specificity, in which compounds bind to two short AT sites separated by one or two GC base pairs. Using thermal melting, heterocycli...
| Main Author: | |
|---|---|
| Format: | Others |
| Published: |
Digital Archive @ GSU
2012
|
| Subjects: | |
| Online Access: | http://digitalarchive.gsu.edu/chemistry_theses/51 http://digitalarchive.gsu.edu/cgi/viewcontent.cgi?article=1050&context=chemistry_theses |