Elucidation of Mechanisms Underlying Metastatic Melanoma Immune Escape via Suppression of Major Histocompatibility Complex (MHC) II through Dysregulation of the JAK/STAT Pathway
Transcriptional activation of Major Histocompatability Complex (MHC) I and II molecules by the cytokine interferon gamma (IFN-g) is a key step in cell-mediated immunity against pathogens and tumors. Following IFN-g induction, JAK/STAT signaling triggers activation of MHC genes. Recent evidence sugge...
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| Format: | Others |
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ScholarWorks @ Georgia State University
2015
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| Online Access: | http://scholarworks.gsu.edu/biology_diss/155 http://scholarworks.gsu.edu/cgi/viewcontent.cgi?article=1160&context=biology_diss |