Synthesis of Aza-Heterocyclic Monoamidines as Potential DNA Minor Groove Binders, Anti-Trypanosomals, and Boron Neutron Capture Therapy Agents
A series of combilexin-like monoamidines has been synthesized by linking an intercalative unit with the DNA minor groove binder DB 818 via “Click chemistry.” DB 818 is a dicationic minor groove binder that has shown strong binding affinity to AT sequences. The aim was to synthesize novel classes of...
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| Format: | Others |
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ScholarWorks @ Georgia State University
2014
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| Online Access: | http://scholarworks.gsu.edu/chemistry_diss/101 http://scholarworks.gsu.edu/cgi/viewcontent.cgi?article=1106&context=chemistry_diss |