Towards specific DNA aptamers which bind and inhibit WWP1 HECT ubiquitin ligase in the osteoblast
DNA aptamers have been studied since their inception in 1990, but have only targeted membrane and serum proteins in therapeutics. Their potential as inhibitors of protein function is hampered by their inability to efficiently enter cells in order to function. Surmounting this hurdle is worthwhile si...
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| Language: | English |
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The University of Hong Kong (Pokfulam, Hong Kong)
2014
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| Online Access: | http://hdl.handle.net/10722/205640 |