A Continuous Optimization Approach To Protein Design With Structural And Functional Constraints
We have developed a novel computational approach to functional de novo protein design using gradient based continuous optimization techniques. Motivated by many engineering applications in which a cost function is optimized subject to a set of constraints, we pose a functional protein design task as...
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Language: | en_US |
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2013
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Online Access: | http://etd.iisc.ernet.in/handle/2005/1979 http://etd.ncsi.iisc.ernet.in/abstracts/2564/G24980-Abs.pdf |