Notch1-Induced Survival Signaling And Its Implications In Cancer Therapeutics

Notch receptors and ligands are type I transmembrane proteins that regulate development and differentiation during cell-cell contact. There are four Notch receptor homologues and five notch ligands, identified in humans till date. Upon ligand activation, Notch1 intracellular domain (NIC-1) is rele...

Full description

Bibliographic Details
Main Author: Mungamuri, Sathish Kumar
Other Authors: Somasundaram, Kumarvel
Published: 2009
Online Access: