Notch1-Induced Survival Signaling And Its Implications In Cancer Therapeutics
Notch receptors and ligands are type I transmembrane proteins that regulate development and differentiation during cell-cell contact. There are four Notch receptor homologues and five notch ligands, identified in humans till date. Upon ligand activation, Notch1 intracellular domain (NIC-1) is rele...
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| Language: | en_US |
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2009
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| Online Access: | http://hdl.handle.net/2005/455 |