The identification of increased Dyrk1a protein levels in Ts65Dn mice guides the targeted administration of the novel Dyrk1a inhibitor CX-4945
Indiana University-Purdue University Indianapolis (IUPUI) === Down syndrome (DS) is caused by three copies of human chromosome 21 (Hsa21) and results in phenotypes including intellectual disability. Ts65Dn mice, the most extensively studied DS model, have three copies of ~50% of the genes on Hsa21 a...
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2018
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| Online Access: | http://hdl.handle.net/1805/16509 https://doi.org/10.7912/C2Q94K |