Transcriptional regulation of ATF4 is critical for controlling the Integrated Stress Response during eIF2 phosphorylation

Transcriptional regulation of ATF4 is critical for controlling the Integrated Stress Response during eIF2 phosphorylation

Indiana University-Purdue University Indianapolis (IUPUI) === In response to different environmental stresses, phosphorylation of eIF2 (eIF2P) represses global translation coincident with preferential translation of ATF4. ATF4 is a transcriptional activator of the integrated stress response, a pro...

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Bibliographic Details
Main Author: Dey, Souvik
Other Authors: Wek, Ronald C.
Language:en_US
Published: 2012
Subjects:
Transcriptional regulation
ATF4
Gene expression
Gene regulatory networks
Genetic translation
Stress (Physiology)
Transcription factors
RNA-protein interactions
Cell receptors > Research
RNA > Metabolism
Proteins > Metabolism > Regulation
Proteins > Synthesis
Proteomics > Methodology
Cellular signal transduction
Phosphorylation > Research > Methodology
Eukaryotic cells
Online Access:http://hdl.handle.net/1805/3041

Internet

http://hdl.handle.net/1805/3041

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