Characterization of recombinant HSV-GFP reporter viruses
VP16 initiates the HSV replication cycle by activating immediate early (IE) gene expression. It recruits the RNA pol II through an acidic C-terminal domain. The defective VP16 encoded by the V422 mutant of HSV-1 possesses a truncated C-terminal domain. Therefore, V422 replication is suppressed in mo...
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| Format: | Others |
| Language: | en |
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2011
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| Online Access: | http://hdl.handle.net/10048/1887 |