Coupling extrasynaptic NMDA receptors to aberrant intracellular signaling in Huntington disease
N-methyl-D-aspartate glutamate receptors (NMDARs) play dichotomous roles on neuronal survival, depending on their surface localization: while synaptic NMDARs promote pro-survival pathways, those expressed at extrasynaptic sites (Ex-NMDARs) trigger pro-death cascades. In the YAC128 transgenic mouse m...
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| Language: | English |
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University of British Columbia
2013
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| Online Access: | http://hdl.handle.net/2429/44572 |