Regulation of beta-amyloid secretion in vitro through p-glycoprotein
The ~4 kDa β-amyloid (Aβ) peptide is believed to be central to the pathogenesis of Alzheimer's disease (AD). Aβ is formed by cleavage of the amyloid precursor protein (APP) through what is known as the amyloidogenic pathway. An alternate nonamyloidogenic pathway cleaves within the Aβ sequenc...
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| Language: | English |
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2009
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| Online Access: | http://hdl.handle.net/2429/13572 |