Checkpoint inhibition and cell cycle effects of 13-hydroxy-15-oxozoapatlin, ent-kaur-16-en-15-oxo-18-9oic acid, and isogranulatimide
Cell cycle checkpoints are activated in response to DNA damage and cause arrest in G₁ and G₂ phase. Inhibitors of the G₂ checkpoint are sought because they can increase the effectiveness of DNA damaging cancer therapies against cells with mutant p53. These inhibitors also have potential value as...
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Language: | English |
Published: |
2009
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Online Access: | http://hdl.handle.net/2429/14866 |