The impact of genetic variation in ABCA1 on cholesterol metabolism, atherosclerosis and diabetes
The ATP-binding cassette transporter, sub-family A, member 1 (ABCA1) mediates the major pathway for cholesterol exit from non-hepatic cells and thereby controls the rate-limiting step in the biogenesis of high density lipoprotein (HDL) particles. In humans,ABCA1 deficiency results in Tangier disease...
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| Language: | en |
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University of British Columbia
2008
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| Online Access: | http://hdl.handle.net/2429/400 |