Mechanism of inhibition of adenylyl cyclase by muscarinic receptor stimulation of inhibitory g-proteins in cardiac muocytes: a biochemical approach

In the mammalian myocardium, adenylyl cyclase is under dual regulation by p adrenoceptors and muscarinic receptors via stimulatory (Gs) and inhibitory (Gj) G proteins. It is well known that activation of Gs upon stimulation of p adrenoceptors cause increase in adenylyl cyclase activity. However,...

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Bibliographic Details
Main Author: Ramaswamy, Subramanian
Language:English
Published: 2009
Online Access:http://hdl.handle.net/2429/5795