Total synthesis of (+)-8-isocyano-10-cycloamphilectene
A 36-step synthesis of the tetracyclic diterpene (+)-8-isocyano-10-cycloamphilectene (11) from (R)-pulegone (40) is described. An efficient four-step process gave 38 from 40 with complete regioselectivity in the introduction of the carbon-carbon double bond. Methoxycarbonylation and reduction wer...
| Main Author: | |
|---|---|
| Language: | English |
| Published: |
2009
|
| Online Access: | http://hdl.handle.net/2429/8588 |