Silencing mutant Huntingtin by RNA interference for the treatment of Huntington Disease
Huntington Disease (HD) is a dominantly inherited neurological disease attributed to a CAG expansion within the HD gene. The HD mutation gives rise to a polyglutamine expansion in exon 1 of the protein huntingtin (Htt). Since the discovery of the HD mutation in 1993, various HD gene mouse models hav...
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| Language: | English |
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University of British Columbia
2008
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| Online Access: | http://hdl.handle.net/2429/937 |