Targeting IL-12 and/or IL-23 by employing peptide-based vaccines in the amelioration of murine colitis

Overexpression of IL-12 and IL-23 has been implicated in the pathogenesis of Crohn’s disease. Targeting these cytokines with monoclonal antibodies has emerged as an effective therapy, but one with adverse reactions. In this study, we sought to develop peptide-based virus-like particle vaccines speci...

Full description

Bibliographic Details
Main Author: Guan, Qingdong
Other Authors: Peng, Zhikang (Immunology)
Published: Elsevier 2012
Subjects:
Online Access:http://hdl.handle.net/1993/8113