Targeting IL-12 and/or IL-23 by employing peptide-based vaccines in the amelioration of murine colitis
Overexpression of IL-12 and IL-23 has been implicated in the pathogenesis of Crohn’s disease. Targeting these cytokines with monoclonal antibodies has emerged as an effective therapy, but one with adverse reactions. In this study, we sought to develop peptide-based virus-like particle vaccines speci...
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Elsevier
2012
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| Online Access: | http://hdl.handle.net/1993/8113 |