Structure and Properties of C8-Aryl-2'-Deoxyguanosine Adducts: From Mutagenic Lesions to Conformational Probes in Duplex DNA

Structure and Properties of C8-Aryl-2'-Deoxyguanosine Adducts: From Mutagenic Lesions to Conformational Probes in Duplex DNA

A significant focus of toxicological research is the identification of electrophiles that covalently modify DNA to form addition products (adducts). These products can be generated when aryl radical species react at the C8-site of 2'-deoxyguanosine (dG) to form C8-aryl-dG adducts, which are mu...

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Bibliographic Details
Main Author: Rankin, Katherine M.
Other Authors: Manderville, Richard A.
Language:en
Published: 2012
Subjects:
DNA modification
nucleoside adduct formation
mutagenic lesion
hydrolytic stability of nucleoside adducts
nucleoside adduct synthesis by Suzuki coupling
synthesis of modified oligonucleotides
nucleoside adducts as fluorescent probes
nucleoside adducts as conformational probes
Online Access:http://hdl.handle.net/10214/4935

Internet

http://hdl.handle.net/10214/4935

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