An Investigation of the Molecular Determinants of Substrate Channeling and Allosteric Activation in Aldolase-Dehydrogenase Complexes
The aldolase-dehydrogenase complex catalyzes the last two steps in the microbial meta-cleavage pathway of various aromatic compounds including polychlorinated biphenyls (bph pathway) and cholesterol (hsa pathway). The aldolase, BphI, cleaves 4-hydroxy-2-oxoacids to produce pyruvate and an aldehyde....
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| Language: | en |
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2013
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| Online Access: | http://hdl.handle.net/10214/6623 |