Investigating the relationship between the RET receptor, Cbl and ARHGEF7 in downregulation of RET

The RET proto-oncogene encodes a receptor tyrosine kinase (RTK), with two major isoforms, RET9 and RET51, which differ in their C-termini, and therefore recruit different signaling complexes. RET plays an important role in cell growth, differentiation, migration and survival. Regulation of RET is cr...

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Bibliographic Details
Main Author: Kaur, Harvinder
Other Authors: Queen's University (Kingston, Ont.). Theses (Queen's University (Kingston, Ont.))
Format: Others
Language:en
en
Published: 2008
Subjects:
RET
Cbl
Online Access:http://hdl.handle.net/1974/1313