THE ROLE OF ALDEHYDE DEHYDROGENASE 2 IN NITRATE TOLERANCE
Organic nitrates such as glyceryl trinitrate (GTN) are commonly used to treat myocardial ischemia and congestive heart failure. GTN is proposed to act as a prodrug that requires bioactivation for pharmacological activity. However, continuous administration results in tolerance development, limiting...
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| Format: | Others |
| Language: | en en |
| Published: |
2008
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| Online Access: | http://hdl.handle.net/1974/1555 |