Mechanisms of Amiodarone and Desethylamiodarone Cytotoxicity in Human Lung Cells

Mechanisms of Amiodarone and Desethylamiodarone Cytotoxicity in Human Lung Cells

Amiodarone (AM) is a potent antidysrhythmic agent which can cause potentially life-threatening pulmonary fibrosis, and N-desethylamiodarone (DEA) is a metabolite of AM that may contribute to the toxicity of AM in vivo. Recent evidence has implicated the involvement of the renin-angiotensin system (...

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Bibliographic Details
Main Author: BLACK, JEANNE
Other Authors: Queen's University (Kingston, Ont.). Theses (Queen's University (Kingston, Ont.))
Format: Others
Language:en
en
Published: 2009
Subjects:
Amiodarone
Desethylamiodarone
vitamin E
Renin-angiotensin system
Online Access:http://hdl.handle.net/1974/5334

Internet

http://hdl.handle.net/1974/5334

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