The RET receptor tyrosine kinase: mechanism, signaling and therapeutics

The RET receptor tyrosine kinase: mechanism, signaling and therapeutics

The RET receptor tyrosine kinase has essential roles in cell survival, differentiation, and proliferation. Oncogenic activation of RET causes the cancer syndrome multiple endocrine neoplasia type 2 (MEN 2), and is a frequent event in sporadic thyroid carcinomas. Multiple endocrine neoplasia 2B (MEN...

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Bibliographic Details
Main Author: Gujral, Taranjit Singh
Other Authors: Queen's University (Kingston, Ont.). Theses (Queen's University (Kingston, Ont.))
Language:en
en
Published: 2008
Subjects:
RET
Receptor Tyrosine Kinase
MEN 2B
Small molecule inhibitor
Thyroid Cancer
Beta-catenin
Online Access:http://hdl.handle.net/1974/5704

Internet

http://hdl.handle.net/1974/5704

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