The Role of Neu1 Sialidase in Epidermal Growth Factor Receptor Activation
The epidermal growth factor receptor (EGFR) exists as a single, highly glycosylated subunit receptor on the plasma membrane of a cell. Upon ligand binding to its extracellular domain, the EGFR dimerizes with an adjacent receptor. This results in activation of the EGFR’s intracellular tyrosine kinase...
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| Language: | en en |
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2011
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| Online Access: | http://hdl.handle.net/1974/6582 |