Understanding the Hippo-LATS pathway in tumorigenesis
The Hippo-LATS signaling pathway originally identified in Drosophila is conserved in mammalian systems and serves essential roles in mediating size control as well as tumorigenesis. In humans, the core kinase cassette consisting of adaptor proteins WW45 and MOB1, and Ser/Thr kinases MST1/2 and LATS...
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| Language: | en en |
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2011
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| Online Access: | http://hdl.handle.net/1974/6751 |