Novel Functions of IL-27 in Innate Immunity: Characterization of IL-27-induced Inflammatory Responses in Human Monocytes and Impact of HIV Infection on IL-27 Expression and Function

Novel Functions of IL-27 in Innate Immunity: Characterization of IL-27-induced Inflammatory Responses in Human Monocytes and Impact of HIV Infection on IL-27 Expression and Function

Interleukins, cytokines secreted by leukocytes, are predominant messengers modulating immune responses. Interleukin-27 (IL-27), a key immunomodulatory cytokine, functions to induce both pro- and anti-inflammatory effects in various immune cells. IL-27 is a heterodimeric cytokine, composed of IL-27p2...

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Bibliographic Details
Main Author: Guzzo, Christina
Other Authors: Queen's University (Kingston, Ont.). Theses (Queen's University (Kingston, Ont.))
Language:en
en
Published: 2012
Subjects:
cytokine
HIV
interleukin-27
TLR4
monocyte
BST-2
STAT
NF-kappa B
Online Access:http://hdl.handle.net/1974/7057

Internet

http://hdl.handle.net/1974/7057

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