THE EFFECT OF HYPOXIA INDUCIBLE FACTOR-1 ON THE EXPRESSION OF THE COINHIBITORY LIGANDS B7-H3 AND B7-H1 IN CANCER: RELEVANCE TO CANCER IMMUNE ESCAPE
The interactions between tumour cells and cells of the immune system are important in the natural evolution of cancer, and the acquired immune system plays an integral role in cancer immune escape. B7-H3 and B7-H1 ligands provide coinhibitory signals to T cells resulting in T cell anergy or apoptosi...
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| Language: | en en |
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2012
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| Online Access: | http://hdl.handle.net/1974/7374 |