CHARACTERIZING VALPROIC ACID-INDUCED DNA DOUBLE STRAND BREAK REPAIR
The teratogenic effects of valproic acid (VPA) are well known, though its teratogenic mechanism remains unknown. VPA induces oxidative stress, which may lead to double strand breaks (DSBs) in DNA. Though the cell may repair this damage via homologous recombination (HR) and non-homologous end joining...
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Language: | en en |
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2012
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Online Access: | http://hdl.handle.net/1974/7597 |