CHARACTERIZING VALPROIC ACID-INDUCED DNA DOUBLE STRAND BREAK REPAIR

CHARACTERIZING VALPROIC ACID-INDUCED DNA DOUBLE STRAND BREAK REPAIR

The teratogenic effects of valproic acid (VPA) are well known, though its teratogenic mechanism remains unknown. VPA induces oxidative stress, which may lead to double strand breaks (DSBs) in DNA. Though the cell may repair this damage via homologous recombination (HR) and non-homologous end joining...

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Bibliographic Details
Main Author: Cutler, Geoffrey Lloyd
Other Authors: Queen's University (Kingston, Ont.). Theses (Queen's University (Kingston, Ont.))
Language:en
en
Published: 2012
Subjects:
pKZ1
Valproic acid
RAD51
XRCC4
DNA double strand breaks
Homologous recombination
Non-homologous end joining
Neural tube defects
Online Access:http://hdl.handle.net/1974/7597

Internet

http://hdl.handle.net/1974/7597

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