Validation of a Gene-Expression Based Assay for BRCA1 Function

Breast cancer is a disease that afflicts a significant proportion of women globally. 5-10% of breast cancer cases are linked to inherited polymorphisms in critical genes such as BRCA1, a tumour suppressor essential for genomic stability. A dysfunctional BRCA1 gene can increase breast cancer risk by...

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Bibliographic Details
Main Author: Uy, PAOLO MIGUEL
Other Authors: Queen's University (Kingston, Ont.). Theses (Queen's University (Kingston, Ont.))
Language:en
en
Published: 2013
Subjects:
Online Access:http://hdl.handle.net/1974/8326